2,031 research outputs found
Quasi-Two-Body Decays of Nonstrange Baryons
We examine the decays of nonstrange baryons to the final states ,
, , , , , and
, in a relativized pair-creation() model which has
been developed in a previous study of the decays of the same baryon
states. As it is our goal to provide a guide for the possible discovery of new
baryon states at CEBAF and elsewhere, we examine the decays of resonances which
have already been seen in the partial-wave analyses, along with those of states
which are predicted by the quark model but which remain undiscovered. The level
of agreement between our calculation and the available widths from the
partial-wave analyses is encouraging.Comment: 41 pages, CEBAF-TH-93-1
New Baryons in the Delta eta and Delta omega Channels
The decays of excited nonstrange baryons into the final states Delta eta and
Delta omega are examined in a relativized quark pair creation model. The
wavefunctions and parameters of the model are fixed by previous calculations of
N pi and N pi pi, etc., decays through various quasi-two body channels
including N eta and N omega. Our results show that the combination of
thresholds just below the region of interest and the isospin selectivity of
these channels should allow the discovery of several new baryons in such
experiments.Comment: 10 pages, RevTe
A (p/E) Calculation of Strong Pionic Decays of Baryons
Strong pionic decays of baryons are studied in a non-relativistic quark model
framework via a convergent (p/E) expansion of the transition operator. Results
are compared to the ones obtained within a more conventional (p/m) expansion.Comment: 16 pages, LaTeX, using amssymb.st
Evidence for the fourth P11 resonance predicted by the constituent quark model
It is pointed out that the third of five low-lying P11 states predicted by a
constituent quark model can be identified with the third of four states in a
solution from a three-channel analysis by the Zagreb group. This is one of the
so-called ``missing'' resonances, predicted at 1880 MeV. The fit of the Zagreb
group to the pi N -> eta N data is the crucial element in finding this fourth
resonance in the P11 partial wave.Comment: 8 pages, revtex; expanded acknowledgement
Strange Decays of Nonstrange Baryons
The strong decays of excited nonstrange baryons into the final states Lambda
K, Sigma K, and for the first time into Lambda(1405) K, Lambda(1520) K,
Sigma(1385) K, Lambda K*, and Sigma K*, are examined in a relativized quark
pair creation model. The wave functions and parameters of the model are fixed
by previous calculations of N pi and N pi pi, etc., decays. Our results show
that it should be possible to discover several new negative parity excited
baryons and confirm the discovery of several others by analyzing these final
states in kaon production experiments. We also establish clear predictions for
the relative strengths of certain states to decay to Lambda(1405) K and
Lambda(1520) K, which can be tested to determine if a three-quark model of the
Lambda(1405) K is valid. Our results compare favorably with the results of
partial wave analyses of the limited existing data for the Lambda K and Sigma K
channels. We do not find large Sigma K decay amplitudes for a substantial group
of predicted and weakly established negative-parity states, in contrast to the
only previous work to consider decays of these states into the strange final
states Lambda K and Sigma K.Comment: 25 pages, 8 figures, RevTe
Distinguishing Among Strong Decay Models
Two competing models for strong hadronic decays, the and
models, are currently in use.
Attempts to rule out one or the other have been hindered by a poor
understanding of final state interactions and by ambiguities in the treatment
of relativistic effects.
In this article we study meson decays in both models, focussing on certain
amplitude ratios for which the relativistic uncertainties largely cancel out
(notably the ratios in and
), and using a Quark Born Formalism to estimate the
final state interactions.
We find that the model is strongly favoured.
In addition, we predict a amplitude ratio of for the decay
.
We also study the parameter-dependence of some individual amplitudes (as
opposed to amplitude ratios), in an attempt to identify a ``best'' version of
the model.Comment: 20 pages, uuencoded postscript file with 7 figures, MIT-CTP-2295;
CMU-HEP94-1
Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer
The epidermal growth factor receptor (EGFR) is historically the prototypical receptor
tyrosine kinase, being the first cloned and the first where the importance of ligand-induced dimer
activation was ascertained. However, many years of structure determination has shown that EGFR is
not completely understood. One challenge is that the many structure fragments stored at the PDB only
provide a partial view because full-length proteins are flexible entities and dynamics play a key role in
their functionality. Another challenge is the shortage of high-resolution data on functionally important
higher-order complexes. Still, the interest in the structure/function relationships of EGFR remains
unabated because of the crucial role played by oncogenic EGFR mutants in driving non-small cell
lung cancer (NSCLC). Despite targeted therapies against EGFR setting a milestone in the treatment
of this disease, ubiquitous drug resistance inevitably emerges after one year or so of treatment.
The magnitude of the challenge has inspired novel strategies. Among these, the combination of
multi-disciplinary experiments and molecular dynamic (MD) simulations have been pivotal in
revealing the basic nature of EGFR monomers, dimers and multimers, and the structure-function
relationships that underpin the mechanisms by which EGFR dysregulation contributes to the onset of
NSCLC and resistance to treatment
Ethanol reversal of tolerance to the respiratory depressant effects of morphine
Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different effects of the drugs. Many opioid addicts regularly consume alcohol (ethanol), and post-mortem analyses of opioid overdose deaths have revealed an inverse correlation between blood morphine and ethanol levels. In the present study, we determined whether ethanol reduced tolerance to the respiratory depressant effects of opioids. Mice were treated with opioids (morphine, methadone, or buprenorphine) for up to 6 days. Respiration was measured in freely moving animals breathing 5% CO(2) in air in plethysmograph chambers. Antinociception (analgesia) was measured as the latency to remove the tail from a thermal stimulus. Opioid tolerance was assessed by measuring the response to a challenge dose of morphine (10 mg/kg i.p.). Tolerance developed to the respiratory depressant effect of morphine but at a slower rate than tolerance to its antinociceptive effect. A low dose of ethanol (0.3 mg/kg) alone did not depress respiration but in prolonged morphine-treated animals respiratory depression was observed when ethanol was co-administered with the morphine challenge. Ethanol did not alter the brain levels of morphine. In contrast, in methadone- or buprenorphine-treated animals no respiratory depression was observed when ethanol was co-administered along with the morphine challenge. As heroin is converted to morphine in man, selective reversal of morphine tolerance by ethanol may be a contributory factor in heroin overdose deaths
Phenomenological study of hadron interaction models
We present a phenomenological study of three models with different effective
degrees of freedom: a Goldstone Boson Exchange (GBE) model which is based on
quark-meson couplings, the quark delocalization, color screening model (QDCSM)
which is based on quark-gluon couplings with delocalized quark wavefunctions,
and the Fujiwara-Nijmegen (FN) mixed model which includes both quark-meson and
quark-gluon couplings. We find that for roughly two-thirds of 64 states
consisting of pairs of octet and decuplet baryons, the three models predict
similar effective baryon-baryon interactions. This suggests that the three very
different models, based on different effective degrees of freedom, are
nonetheless all compatible with respect to baryon spectra and baryon-baryon
interactions. We also discuss the differences between the three models and
their separate characteristics.Comment: 30 pages latex, 7 tables, 12 figs; submitted to Phys. Rev.
Simulation of propofol anaesthesia for intracranial decompression using brain hypothermia treatment
<p>Abstract</p> <p>Background</p> <p>Although propofol is commonly used for general anaesthesia of normothermic patients in clinical practice, little information is available in the literature regarding the use of propofol anaesthesia for intracranial decompression using brain hypothermia treatment. A novel propofol anaesthesia scheme is proposed that should promote such clinical application and improve understanding of the principles of using propofol anaesthesia for hypothermic intracranial decompression.</p> <p>Methods</p> <p>Theoretical analysis was carried out using a previously-developed integrative model of the thermoregulatory, hemodynamic and pharmacokinetic subsystems. Propofol kinetics is described using a framework similar to that of this model and combined with the thermoregulation subsystem through the pharmacodynamic relationship between the blood propofol concentration and the thermoregulatory threshold. A propofol anaesthesia scheme for hypothermic intracranial decompression was simulated using the integrative model.</p> <p>Results</p> <p>Compared to the empirical anaesthesia scheme, the proposed anaesthesia scheme can reduce the required propofol dosage by more than 18%.</p> <p>Conclusion</p> <p>The integrative model of the thermoregulatory, hemodynamic and pharmacokinetic subsystems is effective in analyzing the use of propofol anaesthesia for hypothermic intracranial decompression. This propofol infusion scheme appears to be more appropriate for clinical application than the empirical one.</p
- …